Visual Persuasion in COVID-19 Social Media Content: A Multi-Modal Characterization (preprint)

Social media content routinely incorporates multi-modal design to covey information and shape meanings, and sway interpretations toward desirable implications, but the choices and outcomes of using both texts and visual images have not been sufficiently studied. This work proposes a computational approach to analyze the outcome of persuasive information in multi-modal content, focusing on two aspects, popularity and reliability, in COVID-19-related news articles shared on Twitter. The two aspects are intertwined in the spread of misinformation: for example, an unreliable article that aims to misinform has to attain some popularity. This work has several contributions. First, we propose a multi-modal (image and text) approach to effectively identify popularity and reliability of information sources simultaneously. Second, we identify textual and visual elements that are predictive to information popularity and reliability. Third, by modeling cross-modal relations and similarity, we are able to uncover how unreliable articles construct multi-modal meaning in a distorted, biased fashion. Our work demonstrates how to use multi-modal analysis for understanding influential content and has implications to social media literacy and engagement.

Characterizing User Susceptibility to COVID-19 Misinformation on Twitter (preprint)

Though significant efforts such as removing false claims and promoting reliable sources have been increased to combat COVID-19 "misinfodemic", it remains an unsolved societal challenge if lacking a proper understanding of susceptible online users, i.e., those who are likely to be attracted by, believe and spread misinformation. This study attempts to answer {\it who} constitutes the population vulnerable to the online misinformation in the pandemic, and what are the robust features and short-term behavior signals that distinguish susceptible users from others. Using a 6-month longitudinal user panel on Twitter collected from a geopolitically diverse network-stratified samples in the US, we distinguish different types of users, ranging from social bots to humans with various level of engagement with COVID-related misinformation. We then identify users' online features and situational predictors that correlate with their susceptibility to COVID-19 misinformation. This work brings unique contributions: First, contrary to the prior studies on bot influence, our analysis shows that social bots' contribution to misinformation sharing was surprisingly low, and human-like users' misinformation behaviors exhibit heterogeneity and temporal variability. While the sharing of misinformation was highly concentrated, the risk of occasionally sharing misinformation for average users remained alarmingly high. Second, our findings highlight the political sensitivity activeness and responsiveness to emotionally-charged content among susceptible users. Third, we demonstrate a feasible solution to efficiently predict users' transient susceptibility solely based on their short-term news consumption and exposure from their networks. Our work has an implication in designing effective intervention mechanism to mitigate the misinformation dissipation.

Proceedings of KDD 2020 Workshop on Data-driven Humanitarian Mapping: Harnessing Human-Machine Intelligence for High-Stake Public Policy and Resilience Planning (preprint)

Humanitarian challenges, including natural disasters, food insecurity, climate change, racial and gender violence, environmental crises, the COVID-19 coronavirus pandemic, human rights violations, and forced displacements, disproportionately impact vulnerable communities worldwide. According to UN OCHA, 235 million people will require humanitarian assistance in 2021 . Despite these growing perils, there remains a notable paucity of data science research to scientifically inform equitable public policy decisions for improving the livelihood of at-risk populations. Scattered data science efforts exist to address these challenges, but they remain isolated from practice and prone to algorithmic harms concerning lack of privacy, fairness, interpretability, accountability, transparency, and ethics. Biases in data-driven methods carry the risk of amplifying inequalities in high-stakes policy decisions that impact the livelihood of millions of people. Consequently, proclaimed benefits of data-driven innovations remain inaccessible to policymakers, practitioners, and marginalized communities at the core of humanitarian actions and global development. To help fill this gap, we propose the Data-driven Humanitarian Mapping Research Program, which focuses on developing novel data science methodologies that harness human-machine intelligence for high-stakes public policy and resilience planning. The proceedings of the 1st Data-driven Humanitarian Mapping workshop at the 26th ACM SIGKDD Conference on Knowledge Discovery & Data Mining, August 24th, 2020.

De novo design of ACE2 protein decoys to neutralize SARS-CoV-2 (preprint)

There is an urgent need for the ability to rapidly develop effective countermeasures for emerging biological threats, such as the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes the ongoing coronavirus disease 2019 (COVID-19) pandemic. We have developed a generalized computational design strategy to rapidly engineer de novo proteins that precisely recapitulate the protein surface targeted by biological agents, like viruses, to gain entry into cells. The designed proteins act as decoys that block cellular entry and aim to be resilient to viral mutational escape. Using our novel platform, in less than ten weeks, we engineered, validated, and optimized de novo protein decoys of human angiotensin-converting enzyme 2 (hACE2), the membrane-associated protein that SARS-CoV-2 exploits to infect cells. Our optimized designs are hyperstable de novo proteins ([~]18-37 kDa), have high affinity for the SARS-CoV-2 receptor binding domain (RBD) and can potently inhibit the virus infection and replication in vitro. Future refinements to our strategy can enable the rapid development of other therapeutic de novo protein decoys, not limited to neutralizing viruses, but to combat any agent that explicitly interacts with cell surface proteins to cause disease.